Another Flagellum Excites Scientists

first_img“The bacterial flagellar motor excites considerable interest because of the ordered expression of its genes, its regulated self-assembly, the complex interactions of its many proteins, and its startling mechanical abilities,” begins a paper in Nature by three Caltech scientists.1  They performed electron cryotomography imaging on the flagella of Triponema primita, a different critter with a different model from the flagellum found in E. coli, the favorite toy of microbiologists (with an outboard motor that is an icon of the intelligent design movement).  Treponema is a little spirochete that lives in the hindgut of termites.  It has two flagella, one at each end, that apparently rotate on its inside and make the organism gyrate rather than swim through liquid.    The Caltech team got good images of the stator for the first time.  Their exterior and cross-section illustrations show a multi-part circular structure with 16-fold symmetry and complex contours, with rings and other parts of unknown function.  This particular motor apparently operates in low gear.  It is larger than the E. coli or Salmonella flagella and apparently runs at much higher torque. These differences have important implications for current models of the functional and architectural relationships of the components.  Whereas the Salmonella motor spins just the flagellum, because Treponema flagella are periplasmic, it is thought that they cause the whole cell to gyrate.  Thus, each rotation may be much slower and require greater torque.  The unusually large stud ring, C ring and rotor in Treponema may serve to increase torque by increasing the length of the effective lever arm through which each stator stud acts.  These larger rings may also accommodate more stator studs and FliG molecules around the ring, in effect ‘gearing down’ the Treponema motor so that the passage of each proton across the membrane produces a smaller angular rotation.The paper includes a link to an animation video that shows the motor in operation from different angles.  The authors talk a lot about machine specs, but don’t mention anything about evolution.1Murphy, Leadbetter and Jensen, “In situ structure of the complete Treponema primitia flagellar motor,” Nature 442, 1062-1064(31 August 2006) | doi:10.1038/nature05015.Who would have ever thought that some tiny little bug living inside another bug would possess some of the most elaborate nanotechnology in the world.  Early microscopists like Leeuwenhoek were astonished at the motions of microscopic animalcules, but the true wonder at what makes them move is still just now coming to light.    We hate to keep beating the Darwiniacs over the head with this high-tech motorized wet noodle, but it’s kind of fun in a perverse way.  Besides, incorrigibility deserves flagellation.(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

PHIUS Announces Plans for its Annual Conference

first_imgThe annual conference of the Passive House Institute U.S. is scheduled to take place this year in Chicago and will feature educational sessions on topics ranging from affordable multifamily buildings and modeling software to rammed earth construction and foam-free wall assemblies.Workshops will be led by Joseph Lstiburek of the Building Science Corp.; water expert Gary Klein; Maine architect Chris Briley, co-host of Green Building Advisor’s Green Architect’s Lounge; Thorsten Chlupp, a building science consultant in Alaska; Graham Wright, who leads research and development for PHIUS; building scientist William Rose; and a number of others.Four separate tracks of workshops are scheduled on both September 11 and 12. PHIUS also will announce winners of its juried design competition at the conference (the deadline for entry expires August 25).Pre-conference activities include PHIUS+ rater training on September 9 and 10.Katie Swenson, vice president of National Design Initiatives for Enterprise Community Partners, is scheduled to give the keynote speech when the conference opens on September 11. The following day, the lead speaker will be Dr. Hartwig Kuenzel, developer of the WUFI modeling software. Sam Raskin, chief architect of the Building Technologies Office at the U.S. Department of Energy, will wrap things up with closing remarks on September 12.Registration and pricing information is available at the PHIUS conference website.last_img read more

3 UCLA basketball players suspended after theft in China

first_imgQC cops nab robbery gang leader, cohort Makabayan bloc: Duterte suspension order on rice importation only a ‘media stunt’ PLAY LIST 02:46Makabayan bloc: Duterte suspension order on rice importation only a ‘media stunt’00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games “I’ve learned my lesson from this big mistake and I’m a hundred percent sure I’ll never make a mistake like this again. It’s going to make me a better person from here on out.”When it was his turn, Hill said, “I’m sorry for shoplifting. What I did was stupid. I don’t want to be known for this dumb mistake.”“I hope you can forgive my stupid, childish actions,” he added.Riley was the first to speak and he thanked the Pac-12 Conference, several UCLA administrators and his teammates.“You guys mean so much to me,” Riley said of his teammates. “I’m sorry for letting you down.”Athletic director Dan Guerrero also spoke at the news conference, but no one took questions from a large group of media.ADVERTISEMENT Alford didn’t specify what the indefinite suspensions mean, saying only that the three players would have to earn their way back onto the team.He said at some point, the trio may be permitted to join team workouts, meetings and practices, but that timeline has yet to be decided.“We will come to a resolution in short order,” Guerrero said.Earlier Wednesday, Trump tweeted: “Do you think the three UCLA Basketball Players will say thank you President Trump? They were headed for 10 years in jail!”All three players did.“I’d like to thank President Trump and the United States government for the help that they provided us as well,” Ball said.The players were detained in Hangzhou for questioning following allegations of shoplifting last week before the Bruins beat Georgia Tech in their season-opening game in Shanghai. The rest of the UCLA team returned home Saturday.Guerrero said the incident occurred when the team was given 90 minutes of free time on Nov. 6 in Hangzhou.“Those three visited several stores, took items from three stores and returned to the hotel,” he said, without revealing the items taken or their value.The next day, Guerrero said, police arrived at the hotel shared by UCLA and Georgia Tech and interviewed both teams in an attempt to identify the culprits. Police searched the players’ personal belongings and the team bus before identifying Ball, Hill and Riley, he said. Stronger peso trims PH debt value to P7.9 trillion CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Typhoon Kammuri accelerates, gains strength en route to PH No one from Georgia Tech was implicated.Guerrero said the UCLA trio was taken to a police station for questioning, and Alford arrived later, along with basketball administrator Chris Carlson. Guerrero found out while flying to Shanghai.After being arrested, the players remained in custody for questioning and were released on $2,220 bail on Nov. 8. Guerrero said they had to give up their passports and agree to travel restrictions.Upon their release, they remained in a hotel at UCLA’s insistence, not the local police’s, with Carlson and another administrator supervising them, Guerrero said.He said the bail money was refunded by police. Once the charges were withdrawn, the trio acknowledged breaking the law, he said.Guerrero said UCLA provided the resources to help the players and the university is working to see who is responsible for costs and any NCAA implications.Police told the players they could leave the country on Tuesday and they boarded a plane later that day.Guerrero said Alford reminded his team of the expectations for good behavior before they left on the tripand while they were in China.UCLA traveled to China as part of the Pac-12’s global initiative that seeks to popularize the league’s athletic programs and universities overseas. The China Game is in its third year, and while the scandal was developing the league announced that California and Yale will play in next year’s edition.The No. 23 Bruins host Central Arkansas in their home opener on Wednesday night. Japan ex-PM Nakasone who boosted ties with US dies at 101 View comments Serena Williams set to wed in New Orleans — reportscenter_img Flanked by teammates Cody Riley, left, and Jalen Hill, UCLA basketball player LiAngelo Ball reads his statement during a news conference at UCLA Wednesday, Nov. 15, 2017, in Los Angeles. The three players were detained in Hangzhou following allegations of shoplifting last week before a game against Georgia Tech in Shanghai. (AP Photo/Jae C. Hong)LOS ANGELES — Three UCLA basketball players detained for shoplifting at three high-end stores in China publicly apologized Wednesday before coach Steve Alford announced they were being suspended indefinitely.Freshmen LiAngelo Ball, Jalen Hill and Cody Riley won’t be allowed to suit up, practice or travel with the team while the university continues to sort out the circumstances of last week’s incident in Hangzhou, China, Alford said during a news conference at Pauley Pavilion.ADVERTISEMENT Don’t miss out on the latest news and information. MOST READ Brace for potentially devastating typhoon approaching PH – NDRRMC John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding Read Next LATEST STORIES Kammuri turning to super typhoon less likely but possible — Pagasa “These are good young men who have exercised an inexcusable lapse of judgment and now they have to live with that,” Alford said. “They let a lot people down in the process.”“I’m confident that they have already begun to use this experience as a life lesson,” he added.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutBall, Hill and Riley took turns confessing to the theft and apologizing while also thanking President Donald Trump for intervening on their behalf with his Chinese counterpart Xi Jinping. The players had returned to Los Angeles on Tuesday after Chinese authorities withdrew the charges against them.“I’m sorry for stealing from the stores in China,” said Ball, the younger brother of Los Angeles Lakers rookie Lonzo Ball, who played last season at UCLA.last_img read more

10 months agoMan City whiz Sane: Sterling in career best form

first_imgAbout the authorPaul VegasShare the loveHave your say Man City whiz Sane: Sterling in career best formby Paul Vegas10 months agoSend to a friendShare the loveManchester City whiz Leroy Sane says Raheem Sterling must be close to career best form.Sterling already has nine Premier League goals and six assists to his name this season and signed a new deal in November to keep him at the club until 2023.Sane said, “Of course, it’s always important if you have good people around you – good friends. You can trust them also and obviously, it’s very important for our team.“He’s scored a lot of goals and helps us a lot in every way and he’s just a really good guy – a humble guy.”He is also really hungry and motivated to improve in his own game – to achieve something: his own targets.“This is what it’s like to push him to get better and if it goes like this every year, I think soon he can also be one of the best players.” last_img read more

5 days agoWoodward: What Man Utd want in a player…

first_imgAbout the authorPaul VegasShare the loveHave your say Woodward: What Man Utd want in a player…by Paul Vegas5 days agoSend to a friendShare the loveVice-chairman Ed Woodward has set out the prototype of a Manchester United player.Woodward believes manager Ole Gunnar Solskjaer to be a “walking, talking” version of the club’s philosophy. He told United We Stand fanzine, “Winning; playing attacking football with players that have an ‘x-factor’; and giving youth a chance.”Added to that, we want players to come in who respect their teammates, the club, the history. They must understand that they are creating a legacy by coming to Manchester United. Nobody is bigger than the club.”There should be both a humbleness and an arrogance. Humble when you are on the team coach and you wear the club suit, you do up your top button and wear your tie, you represent the club in the right way. Then you sign autographs for the people who pay your wages.”Then, when you go into the dressing room, you put the red shirt on and you feel arrogant, self assured. As Michael Carrick said in his book, you want to take the ball, you want the ball in tight spaces, you want a never-say-die spirit. Ole has brought a lot of the discipline back.”Whatever manager we have has to buy into that philosophy and Ole is a walking, talking version of that. Let’s let this play out with Ole in terms of the culture reboot.” last_img read more

Heart Foundation and Jamaica Cancer Society to get help from FFK

first_imgThe Heart Foundation of Jamaica (HFJ) and the Jamaica Cancer Society (JCS) will be the beneficiaries from the ‘Party for Charity’ event, which is staged annually by Fraser, Fontaine & Kong (FFK) Limited, as part of its corporate social responsibility initiatives. The insurance company intends to offer approximately $1.5 million to both entities from the event, which will be held on Friday, November 2 at the FFK’s car park, 28 Pawsey Place in Kingston.  Speaking at a JIS ‘Think Tank’, on October 30, President of the FFK Limited, Gerard Fontaine, noted that the staging of this event is the company’s way of giving back to Jamaica and supporting the work of two important entities. “These two entities are very dear to our hearts, because we have had a few of our staff members pass away in  recent years from cancer illnesses or heart complications, including our late President, Richard Fontaine, So, this is our way of showing that we care and doing our part to create a better Jamaica,” the President said. He added that the company has been hosting the event for the past six years and has made significant contribution towards the operations of other entities, such as Lupus Foundation and the Fire Brigade. Some 900 patrons are expected at the event. Tickets are $1,500 pre-sold and $1,700 at the gate. Lucky patrons will win one year free membership from HFJ and JCS; two tickets to the James Bond movie, Sky Fall, and a free mammogram. Mr. Fontaine noted that other entities will benefit from initiatives that the company will spearhead, including the Maxfield Park Children’s Home and the College of Insurance for Professionals. The FFK Limited has been in operation since 1972 and offers a range of insurance services, including general insurance, employee benefits and risk management. The company’s services extend throughout Caribbean covering the hospitality, manufacturing, aviation, marine and financial sectors.last_img read more

Ohio State confident in JT Barrett after losing Braxton Miller to injury

OSU redshirt-freshman quarterback J.T. Barrett scans the field during practice at the Woody Hayes Athletic Center Aug. 9.Credit: Mark Batke / Photo editorWhen a team loses its best player, not many expect the days following to be very positive.Ohio State football coach Urban Meyer said that was not the case following the news that senior quarterback Braxton Miller will miss the entirety of the 2014 season after re-injuring his shoulder Monday.“It would be hard to say it wasn’t — maybe the best practice we’ve had since our staff has come to Ohio State,” Meyer said Wednesday. “High energy, especially for practice 20. Really impressed.”On Saturday, Meyer announced redshirt-freshman J.T. Barrett had earned a slight edge on redshirt-sophomore Cardale Jones for the backup quarterback position. With Miller out for the year, Barrett will likely be thrust into the starting role, something in which Meyer said he is confident.“J.T. had about 300 competitive throws this fall, where when (former OSU quarterback) Kenny Guiton went into the game a couple years ago, I think he had six,” Meyer said. “He (Barrett) is a meticulous guy.”Meyer was not shy about comparing Barrett to Guiton, going as far as calling Barrett “Guiton-ish.”Senior cornerback Doran Grant also said he sees similarities between Barrett and Guiton.“J.T. does what KG does. He has had a lot of competitive reps this fall and has been looking pretty good,” Grant said. “They call him ‘The Distributor’ — that’s a good name for him because he is doing what he has to do.”Meyer said he also believes that Barrett’s ability to spread the ball around to the rest of the offense is one of his best skills.“Some of the best quarterbacks are great distributors,” Meyer said. “I thought Kenny Guiton was one of the best I have been around as far as getting the ball out rather quickly and distributing to playmakers…my initial evaluation of J.T. is that he is very good at that.”Grant said he has been impressed with not only Barrett’s play but also his leadership on the team.“I don’t think a lot of guys know this, but he (Barrett) was a part of the leadership committee as a true freshman,” Grant said. “He was the third or fourth quarterback on the depth chart (last season)…he just has those leadership qualities, and that has shown on the field.”Senior tight end Jeff Heuerman echoed Grant’s comments on Barrett and said the young quarterback has other positive qualities to bring to the table as well.“He is a great leader. He is super smart, he’s a hard worker and I think that was the case before this happened,” Heuerman said. “He handles his business and does everything right, and we have full confidence in him and full trust.“We’re behind him 100 percent.”Although the discussion was almost solely focused on Barrett and Miller, Meyer said he will still consider playing both Barrett and Jones week one against Navy.Meyer said both Barrett and Jones have positive qualities to their game.“J.T. has a pretty good release, and he has a good skill level. Cardale has got just a cannon,” Meyer said.Despite the confidence in Barrett, the loss of Miller still was not easy to take at first, Heuerman said.“I was with him when his shoulder was out of place, and I had never seen him like that,” Heuerman said. “He was in pain. So we kind of knew right away that it wasn’t going to be good.”Heuerman said that although Miller is lost for the year, he is confident that the Buckeyes will be fine with Barrett when surrounded by playmakers.“We got a lot of playmakers, and we are going to have to rely on them a lot to make plays,” Heuerman said.The Buckeyes are scheduled to open the 2014 season on Aug. 30 at M&T Bank Stadium in Baltimore against Navy. Kickoff is set for noon. read more